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On one hand, specifically blocking HIF signaling can significantly attenuate hypoxia-driven pathological ROS accumulation

Patients start on a low dose, and then continually increase to a higher dose until treatment goals are achieved

Interestingly, non-pharmacological interventions such as physical exercise (PE) demonstrate protective effects by targeting this pathway in microglia

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2) the addition of a fatty acid using a linker to promote the binding of molecules to serum albumin and thus reduce their elimination at the renal level